Games like Karyofox
Karyofox finishes in about a while. These games share the most with it, and each one says why.

Neon Electrogenesis
Also science, biology · Has an ending
Excite electrons into atoms and build up six elements until you have enough atoms for one cell. A jam game with no text at all.
2.5★ galaxyhas ending
Black Hole FishingUpdated
Also science, biology
Use a black hole to vacuum fish from a pond, then breed, inject traits into and research them while feeding the singularity to grow it.
89% steam
The Fly Devourer Tree
Also biology, animals
Evolve a creature built to eat as many flies as possible, progressing through nine layers so far.
4.3★ galaxy
Idle Lab Rats
Also animals, science
Buy rats, train them in mazes and with lab equipment, and submit the best ones for grant money to expand your lab.
4.3★ galaxy
Bugtopia
Also animals, biology
Raise and breed over 300 real-world insect species in terrariums you landscape yourself, with breeding boxes that can produce rare new bugs.
92% steam
BIOTOMATA
Also biology · Has an ending
Grow a living machine cell by cell. Currently the top-rated game on Galaxy.
4.7★ galaxyhas ending
FEED THE QUEENUpdated
Also animals, biology
Grow an insect-like colony by breeding specialized workers and combining foods, evolving the species via a genetics talent tree.
69% steam
Koltera
Also animals, biology
Mine and train with creatures that each carry genetics, breed them toward perfect stats, trade for rarer species, and grow a garden that summons legendaries.
69% steam
Cell to Singularity: EvolutionUpdated
Also science, biology
Click through the history of life from primordial soup to technology, climbing a science tech tree.

Idle Ant Colony - Sim GameUpdated
Also animals, science
Grow an anthill by hatching workers, laying trails to haul food and researching new tech to found colonies on other continents.
75% idle
Idle evolution: Life on EarthUpdated
Also biology, science
Guide life from the ancient seas to human culture while learning about prehistoric creatures along the way.

Idle HumanUpdated
Also biology, science
Build a human body starting from one cell, adding bones, organs, nerves and muscles along the way.

The Adventure of NAYU
Also animals · Has an ending
Click to help a fox and her party fight through a gentle, short story, spending star shards on training and costumes, with an endless mode afterward.
95% steamhas ending75% idle
Forest Hustle
Also animals · Has an ending
Dropped in a forest with a 100k debt, chop wood, mine stone, trade and hire dog workers until you pay it off.
90% steamhas ending
Intelligent Design: An Evolutionary Sandbox
Also biology, science
Seed a world with plants, herbivores, and carnivores whose genes mutate each generation, then leave it running and return to see what evolved or died out.
45% steam90% idle
Widget Inc.
Also science · Has an ending
Craft widgets by hand, then automate and lay out a sprawling factory through twelve tech tiers on the way to building a rocket.
87% steamhas ending
Lyca
Also animals · Has an ending
A magical wolf runs across a wasteland gathering resources to buy through a large upgrade tree, bringing it back to green in a few hours.
83% steamhas ending
Into the Planet’s FleshUpdated
Also biology · Has an ending
Hatch parasites and spread a grotesque colony through a planet that resists you, with buildings and prestige upgrades. The demo has an ending.
has ending
XiuzhenWorld
Also animals · Has an ending
Cultivate from mortal to immortal in a 3D world, capturing monster pets to fight alongside you and letting an AFK mode grind.
77% steamhas ending50% idle
Raccoon Valley Tycoon
Also animals · Has an ending, about 2–5h
Dig up resources, vacuum up the loot and rebuild an abandoned raccoon village, hats and all.
100% steam2–5h ending65% idle
Idle Evolution
Also science · Has an ending
Combine atoms to grow a rock through eras toward a final evolution, following missions, quizzes and minigames. Despite the name, it is built for active play.
73% steamhas ending25% idle
Fox Evolution - Clicker GameUpdated
Also animals · Has an ending
Combine fox species into odd mutations, tapping eggs for coins, dodging impostors and chasing one of several endings.
has ending
4.6★ galaxy
Budgie's Bug Shop
Also animals
Catch bugs and sell them in a shop staffed by parakeets, buying gear and abilities to grow profits.
4.6★ galaxy